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Study of morphological alterations of the adrenal glands in the neoplastic cachexia

Estudo das alterações morfológicas da glândula adrenal na caquexia neoplásica

dc.creatorFonseca, Eveline Aparecida Isquierdo
dc.creatorMacioszek, Marcelo Abbá
dc.creatorSaito, Alexandre Yukio
dc.creatorCotrim, Karina Garcia
dc.creatorMazzuco, Tânia Longo
dc.date2004-11-29
dc.date.accessioned2022-10-18T19:43:28Z
dc.date.available2022-10-18T19:43:28Z
dc.identifierhttps://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/4345
dc.identifier10.5433/1679-0367.2009v30n2p163
dc.identifier.urihttp://www.labtecgc.udesc.br/tabd1/handle/123456789/551
dc.descriptionAdvanced cancer occurs with nutritional and metabolic alterations that characterize neoplastic cachexia. When homeostasis is compromised, the adrenal glands have a fundamental role in the neuroendocrine response. Our purpose in this research was to study morphological alterations of the adrenal glands in the development of cancer associated to cachexia. Cachexia experimental model induced by Walker 256 tumor in Wistar rats, was used. Animals were sacrificed 12 days after tumor cells inoculation and adrenal glands removal for histopathologic analysis by means of hematoxylin and eosin stain. Nutritional parameters, cachexia index and adrenal glands weight, were evaluated. Animals with tumor presented cachexia index of 16,6 ± 4%. Adrenal glands average weight was significantly higher in the tumor group (40 mg ± 10) than in the control group (25 mg ± 3). Adrenal cortex of animals with cachexia showed hypertrophy of the zona fasciculata and reticular layer, with voluminous spongiocytes; vascular congestion and stasis were observed in the medullar region. Results were similar in the pair and ad libitum-fed groups. Animals with cancer cachexia showed compromised morphology of the adrenal glands which showed alterations related to stress response, suggesting increased cathecolamine secretion and activation of the hypothalamus-pituitary-adrenal axis.  en-US
dc.descriptionAdvanced cancer occurs with nutritional and metabolic alterations that characterize neoplastic cachexia. When homeostasis is compromised, the adrenal glands have a fundamental role in the neuroendocrine response. Our purpose in this research was to study morphological alterations of the adrenal glands in the development of cancer associated to cachexia. Cachexia experimental model induced by Walker 256 tumor in Wistar rats, was used. Animals were sacrificed 12 days after tumor cells inoculation and adrenal glands removal for histopathologic analysis by means of hematoxylin and eosin stain. Nutritional parameters, cachexia index and adrenal glands weight, were evaluated. Animals with tumor presented cachexia index of 16,6 ± 4%. Adrenal glands average weight was significantly higher in the tumor group (40 mg ± 10) than in the control group (25 mg ± 3). Adrenal cortex of animals with cachexia showed hypertrophy of the zona fasciculata and reticular layer, with voluminous spongiocytes; vascular congestion and stasis were observed in the medullar region. Results were similar in the pair and ad libitum-fed groups. Animals with cancer cachexia showed compromised morphology of the adrenal glands which showed alterations related to stress response, suggesting increased cathecolamine secretion and activation of the hypothalamus-pituitary-adrenal axis.    pt-BR
dc.formatapplication/pdf
dc.languagepor
dc.publisherUniversidade Estadual de Londrinapt-BR
dc.relationhttps://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/4345/3650
dc.rightsCopyright (c) 2016 Semina: Ciências Biológicas e da Saúdept-BR
dc.sourceSemina: Ciências Biológicas e da Saúde; Vol. 30 No. 2 (2009); 163-174en-US
dc.sourceSemina: Ciências Biológicas e da Saúde; v. 30 n. 2 (2009); 163-174pt-BR
dc.source1679-0367
dc.source1676-5435
dc.subjectWalker Carcinoma 256en-US
dc.subjectCachexiaen-US
dc.subjectAdrenal Glandsen-US
dc.subjectHPA axis.en-US
dc.subjectWalker Carcinoma 256pt-BR
dc.subjectCachexiapt-BR
dc.subjectAdrenal Glandspt-BR
dc.subjectHPA axis.pt-BR
dc.titleStudy of morphological alterations of the adrenal glands in the neoplastic cachexiaen-US
dc.titleEstudo das alterações morfológicas da glândula adrenal na caquexia neoplásicapt-BR
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeArtigo avaliado pelos Parespt-BR


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